This workshop is a satellite meeting of the 24th International Conference on Plasma Surface Interactions in Controlled Fusion Devices (PSI-24) held on Jan 24 through Jan 29, 2021 as v virtual conference. It follows the tradition of the series of the last fourteen International Workshops on Hydrogen Isotopes in Fusion Reactor Materials (H-Workshop) that were organized as satellite workshops to PSI conferences. As its predecessors it is intended as a platform for experts in the field to present and discuss the latest scientific results. To fulfill its scope as a workshop ample time for discussion will be provided. The workshop will focus on experiments and modeling of hydrogen isotope interactions with fusion-reactor materials with particular emphasis on fuel balance in reactors and the development of tritium removal techniques.